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Escape from planarity in fragment-based drug discovery: A synthetic strategy analysis of synthetic 3D fragment libraries

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Nrf2 also promotes purine base synthesis through the indirect regulation of phosphoribosyl-pyrophosphate amidotransferase (catalyzes the rate-limiting step in purine biosynthesis), and methylenetetrahydrofolate dehydrogenase 2 (a nuclear-encoded mitochondrial enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities) [50]